AT1选择性血管紧张素II受体拮抗剂氯沙坦对异丙肾上腺素诱导的心脏鸟氨酸脱羧酶活性的影响。

Effect of losartan, an AT1 selective angiotensin II receptor antagonist, on isoproterenol-induced cardiac ornithine decarboxylase activity.

作者信息

Nakano M, Kanda T, Matsuzaki S, Hasegawa S, Ma H, Imai S, Suzuki T, Kobayashi I

机构信息

Second Department of Internal Medicine, Gunma University School of Medicine, Japan.

出版信息

Res Commun Mol Pathol Pharmacol. 1995 Apr;88(1):21-30.

PMID:7620835

Abstract

Ornithine decarboxylase (ODC,EC 4.1.1.7), a rate-limiting enzyme in polyamine biosynthesis, is known to be induced by a beta-adrenoceptor agonist, isoproterenol (ISO). ODC activity and cardiac polyamine content are considered to be correlated with ISO-induced cardiac hypertrophy in rat hearts. To determine whether ISO-induced cardiac ODC activity is mediated through the renin-angiotensin system, especially at the AT1-receptor, we used a nonpeptide AT1 receptor antagonist, losartan, in this study. Losartan (10 mg/kg) suppressed both heart ODC and polyamine contents in ISO-treated rats. Although metoprolol (a selective beta-adrenoceptor antagonist) totally suppressed ODC activity, these results suggest that ISO-stimulated cardiac ODC activity may be regulated through beta 2-adrenoceptors coupled with AT1 receptors in rats.

摘要

鸟氨酸脱羧酶（ODC，EC 4.1.1.7）是多胺生物合成中的限速酶，已知可被β-肾上腺素能受体激动剂异丙肾上腺素（ISO）诱导。ODC活性和心脏多胺含量被认为与ISO诱导的大鼠心脏肥大相关。为了确定ISO诱导的心脏ODC活性是否通过肾素-血管紧张素系统介导，尤其是通过AT1受体介导，我们在本研究中使用了非肽类AT1受体拮抗剂氯沙坦。氯沙坦（10 mg/kg）抑制了ISO处理大鼠的心脏ODC和多胺含量。虽然美托洛尔（一种选择性β-肾上腺素能受体拮抗剂）完全抑制了ODC活性，但这些结果表明，ISO刺激的心脏ODC活性可能通过大鼠体内与AT1受体偶联的β2-肾上腺素能受体进行调节。