Brandt-Rauf P W, De Vivo I, Marion M J, Hemminki K
Division of Environmental Sciences, Columbia University, New York, New York 10032, USA.
J Occup Environ Med. 1995 Jan;37(1):77-83. doi: 10.1097/00043764-199501000-00011.
Cellular proteins involved in growth signal transduction pathways represent potential molecular epidemiologic biomarkers for various disease processes of toxicologic interest, particularly cancer. In many instances, the proteins gain access to the extracellular environment and thus can be detected in easily accessible biological fluids such as serum or plasma. This paper reviews the experience with selected examples of such proteins, including growth factors, growth factor receptors, G proteins, and nuclear DNA-binding proteins, as serum or plasma biomarkers of disease.
参与生长信号转导途径的细胞蛋白是毒理学关注的各种疾病过程（尤其是癌症）潜在的分子流行病学生物标志物。在许多情况下，这些蛋白进入细胞外环境，因此可以在血清或血浆等易于获取的生物体液中检测到。本文回顾了将此类蛋白（包括生长因子、生长因子受体、G蛋白和核DNA结合蛋白）选作疾病血清或血浆生物标志物的经验。
