Merigian K S, Browning R G, Leeper K V
Department of Emergency Medicine, University of Tennessee, Memphis, USA.
Acad Emerg Med. 1995 Feb;2(2):128-33. doi: 10.1111/j.1553-2712.1995.tb03177.x.
Tonic-clonic seizure activity is a recognized complication of amoxapine overdose. Refractory drug-induced status epilepticus is associated with significant morbidity and mortality. Standard regimens for controlling status epilepticus may be ineffective for aborting drug-induced seizures. The authors report the case of a 30-year-old woman who presented with an amoxapine overdose that deteriorated into status epilepticus refractory to conventional therapy. Propofol given by intravenous bolus and maintenance infusion successfully halted the patient's seizure activity. This case suggests that propofol may be effective as an anticonvulsant in refractory drug-induced status epilepticus.
强直阵挛性癫痫发作活动是阿莫沙平过量的一种公认并发症。难治性药物性癫痫持续状态与显著的发病率和死亡率相关。控制癫痫持续状态的标准方案可能对中止药物性癫痫发作无效。作者报告了一名30岁女性的病例，该患者因阿莫沙平过量就诊，病情恶化为对传统治疗难治的癫痫持续状态。静脉推注和维持输注丙泊酚成功地终止了患者的癫痫发作活动。该病例表明，丙泊酚在难治性药物性癫痫持续状态中可能作为一种抗惊厥药有效。
