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[自限性脂肪泻与Ⅰ型慢性自身免疫性肝炎。病毒性肝炎与艾滋病研究组]

[Self-limited steatorrhea and chronic autoimmune hepatitis type I. The Group for the Study of Viral Hepatitis and AIDS].

作者信息

Gallardo-Marín J A, Pérez-Romero M, Sánchez-Quijano A, Lissen E

机构信息

Departamento de Medicina Interna, Hospital Universitario Virgen del Rocio, Sevilla.

出版信息

Gastroenterol Hepatol. 1995 Mar;18(3):136-8.

PMID:7621290
Abstract

Active chronic hepatitis is very infrequent in Spain. Its autoimmune pathogenesis is supported by the coexistence of autoimmune features, its usually good response to immunosuppressive treatment and the frequent coexistence of other processes of autoimmune etiology. The infrequent cases of steatorrhea observed may usually be found in the presence of severe colostasis or in association with other diseases such as celiac disease. The presence of sever anemia is also infrequent being observed on hemolysis of digestive bleeding. A case of autoimmune type I chronic hepatitis observed in a 14-year old woman presenting as acute hepatitis associated to severe anemia (Hb, 6,3 g/dl) and self-limited steatorrhea independent of the clinical course of the hepatic picture (stool fats of up to 100 g/24 h) with no evidence of hemolysis, digestive bleeding, obvious colostasis, drug ingestion or demonstrable intestinal or pancreatic disease. The coexistence of these unusual findings led the authors to report this case.

摘要

活动性慢性肝炎在西班牙非常罕见。其自身免疫性发病机制得到以下因素支持:自身免疫特征的共存、通常对免疫抑制治疗的良好反应以及其他自身免疫性病因过程的频繁共存。观察到的罕见脂肪泻病例通常见于严重胆汁淤积或与其他疾病(如乳糜泻)相关的情况。严重贫血的出现也不常见,见于消化性出血的溶血情况。本文报告了一例14岁女性的自身免疫性I型慢性肝炎病例,该病例表现为急性肝炎,伴有严重贫血(血红蛋白,6.3 g/dl)和与肝病临床病程无关的自限性脂肪泻(粪便脂肪高达100 g/24小时),无溶血、消化性出血、明显胆汁淤积、药物摄入或可证实的肠道或胰腺疾病证据。这些不寻常发现的共存促使作者报告此病例。

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