O'Brien R
Department of Medicine, Monash Medical Centre, Clayton, Australia.
J Cardiovasc Risk. 1994 Oct;1(3):207-11. doi: 10.1177/174182679400100304.
Low-density lipoproteins (LDLs) exist as discrete subfractions that vary in size and density. A predominance of small, dense LDLs is seen in patients with ischaemic heart disease and non-insulin-dependent diabetes, and is more common in men than in women. Because small, dense LDLs are associated with increased levels of triglycerides and low levels of high-density-lipoprotein cholesterol, their exact role as an independent cardiovascular risk factor is unknown. These lipoproteins exhibit abnormal characteristics, however, such as increased susceptibility to oxidation and decreased LDL receptor binding, which may result in increased atherogenicity.
低密度脂蛋白（LDLs）以大小和密度各异的离散亚组分形式存在。在缺血性心脏病和非胰岛素依赖型糖尿病患者中，小而密的LDL占主导，且在男性中比在女性中更常见。由于小而密的LDL与甘油三酯水平升高和高密度脂蛋白胆固醇水平降低相关，其作为独立心血管危险因素的确切作用尚不清楚。然而，这些脂蛋白表现出异常特征，如氧化易感性增加和LDL受体结合减少，这可能导致动脉粥样硬化性增加。
