Hsu B, Marin M C, McDonnell T J
Department of Molecular Pathology, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.
Cancer Lett. 1995 Jul 20;94(1):17-23. doi: 10.1016/0304-3835(95)03836-l.
The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mice and p53 knockout mice, have been used to prospectively examine the regulation of apoptotic cell death by these genes, individually and in combination, and their contribution to in vivo lymphomagenesis. The potential importance of the therapeutic induction of apoptosis is discussed.
恶性淋巴瘤中出现的三种最常见的基因异常涉及导致c-myc和bcl-2癌基因表达失调以及p53肿瘤抑制基因失活的改变。包括bcl-2-Ig和Eμ-myc转基因小鼠以及p53基因敲除小鼠在内的相关基因工程小鼠品系已被用于前瞻性地研究这些基因单独和联合对凋亡细胞死亡的调节作用，以及它们在体内淋巴瘤发生中的作用。文中还讨论了凋亡诱导治疗的潜在重要性。
