Herrmann H C, Malosky S A, Guidera S A, DeAngelo D, Hirshfeld J W
Cardiovascular Division, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Cathet Cardiovasc Diagn. 1995 Apr;34(4):286-92. doi: 10.1002/ccd.1810340203.
A comparison of consecutive initial and later patients receiving emergent coronary artery stents to salvage failed PTCA procedures was made to determine whether experience with this procedure can improve patient outcome. Twenty-six consecutive patients underwent emergent, unplanned implantation of one or more Palmaz-Schatz coronary stents at our institution over a 3-1/2 year period. Indications for stent insertion included impending vessel closure (decrease in TIMI flow grade and clinical evidence of ischemia) or acute occlusion (TIMI flow grade 0 or 1 and > or = 99% stenosis) after PTCA. Immediate and final success (30 day) were determined, and the results in the first (Initial) 13 patients were compared to the remaining (Later) 13 patients. Baseline characteristics of the study population included a male predominance (69%) with a mean (+/- SD) age of 57 +/- 10 years. Conventional balloon PTCA was performed in all three native coronary arteries with an increase in mean percentage stenosis from 76 +/- 13 to 85 +/- 14% (P < 0.05). Twelve patients developed acute occlusion and 14 patients impending closure after PTCA due to the appearance of thrombus (12%), dissection (46%), or both (35%). Palmaz-Schatz stents were successfully inserted in all patients restoring TIMI grade 3 antegrade flow; however, major complications developed in almost 50% of patients. Comparison of initial and later patients showed no differences in demographic or pre-PTCA angiographic characteristics. Later patients had less severe stenoses post-PTCA (before stenting) and were less likely to have thrombus present at the angioplasty site (15% vs. 77%, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
对接受紧急冠状动脉支架植入术以挽救失败的经皮冠状动脉腔内血管成形术(PTCA)的连续初治患者和后续患者进行比较,以确定该手术经验是否能改善患者预后。在3年半的时间里,我们机构连续26例患者接受了紧急、非计划性的一个或多个帕尔马兹-施查茨冠状动脉支架植入术。支架置入的指征包括PTCA术后即将发生的血管闭塞(TIMI血流分级降低和缺血的临床证据)或急性闭塞(TIMI血流分级0或1且狭窄≥99%)。确定即刻成功率和最终成功率(30天),并将前13例患者(初治组)的结果与其余13例患者(后续组)的结果进行比较。研究人群的基线特征包括男性占多数(69%),平均(±标准差)年龄为57±10岁。所有三支冠状动脉均进行了传统球囊PTCA,平均狭窄百分比从76±13%增加到85±14%(P<0.05)。12例患者发生急性闭塞,14例患者PTCA术后因血栓形成(12%)、夹层形成(46%)或两者皆有(35%)而即将发生闭塞。所有患者均成功植入帕尔马兹-施查茨支架,恢复TIMI 3级前向血流;然而,近50%的患者出现了严重并发症。初治组和后续组患者在人口统计学或PTCA术前血管造影特征方面无差异。后续组患者PTCA术后(支架置入前)狭窄程度较轻,血管成形术部位出现血栓的可能性较小(15%对77%,P<0.05)。(摘要截断于250字)