心钠素原激素肽的分泌及对肾脏的影响。

Secretion and renal effects of ANF prohormone peptides.

Dietz J R, Vesely D L, Gower W R, Nazian S J

Department of Physiology and Biophysics, University of South Florida College of Medicine, Tampa, USA.

Clin Exp Pharmacol Physiol. 1995 Feb;22(2):115-20. doi: 10.1111/j.1440-1681.1995.tb01966.x.

Abstract

Atrial natriuretic factor (ANF) and pro ANF peptide appears to be secreted simultaneously from the atria in response to atrial stretch. 2. The major peptide forms secreted from rat atria appear to be ANF (pro ANF 99-126) as the primary C-terminal peptide and pro ANF 1-30 as the primary N-terminal peptide, as opposed to 1-67 or 1-98. 3. The plasma concentrations of ANF and pro ANF 1-30 are increased by acute stimulation with blood volume expansion and the plasma levels of ANF and N-terminal ANF prohormone peptides are chronically elevated by high salt diet. 4. Pro ANF 31-67 produces a natriuresis which is not dependent on an increase in renal cGMP excretion, decreases in plasma renin activity (PRA) or elevations in plasma ANF concentration.

摘要

心房利钠因子（ANF）和前ANF肽似乎在心房牵张时从心房同时分泌。2. 大鼠心房分泌的主要肽形式似乎是作为主要C末端肽的ANF（前ANF 99-126）和作为主要N末端肽的前ANF 1-30，而不是1-67或1-98。3. 血容量扩张急性刺激可使ANF和前ANF 1-30的血浆浓度升高，高盐饮食可使ANF和N末端ANF前激素肽的血浆水平长期升高。4. 前ANF 31-67产生利钠作用，这并不依赖于肾cGMP排泄增加、血浆肾素活性（PRA）降低或血浆ANF浓度升高。