Brooks K J, Lowy C, Thomas C R
Department of Pharmacology, St. Thomas' Campus, UMDS, London, UK.
Diabetes Res. 1994;26(3):117-25.
Spectral analysis of spin-echo 1H magnetic resonance spectroscopy (MRS) data has revealed differences in the metabolic profiles of maternal and fetal plasma and placental extracts. Resonances from low-molecular weight components of the normal maternal and fetal plasma were attributed to glucose, lactate, creatine, citrate, amino acids and ketone bodies. There were also signals from lipoprotein molecules associated with lipid-transporting moeties contained in the plasma. The placental extract showed a similar composition to the plasma samples however the spectra were dominated by a large signal attributed to betaine, there was also an absence of signals from citrate, acetoacetate, acetone and lipoproteins. Diabetes caused profound changes in all tissue types indicating high levels of glucose and ketogenic activity. In both the maternal and fetal plasma there were increases in glucose, ketone bodies and valine in the diabetic rats, increases in lactate and alanine were confined to the fetal plasma and placenta. This study indicates that diabetes causes major changes in the composition of fetal plasma which in turn could interfere with the development of the fetus.
自旋回波1H磁共振波谱（MRS）数据的光谱分析揭示了母体和胎儿血浆以及胎盘提取物代谢谱的差异。正常母体和胎儿血浆中低分子量成分的共振归因于葡萄糖、乳酸、肌酸、柠檬酸盐、氨基酸和酮体。血浆中还存在与脂质转运部分相关的脂蛋白分子信号。胎盘提取物显示出与血浆样本相似的成分，然而光谱主要由归因于甜菜碱的大信号主导，同时也没有柠檬酸盐、乙酰乙酸、丙酮和脂蛋白的信号。糖尿病导致所有组织类型发生深刻变化，表明葡萄糖和生酮活性水平较高。在糖尿病大鼠的母体和胎儿血浆中，葡萄糖、酮体和缬氨酸增加，乳酸和丙氨酸的增加仅限于胎儿血浆和胎盘。这项研究表明，糖尿病会导致胎儿血浆成分发生重大变化，进而可能干扰胎儿的发育。
