• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Commentary on interactions between 6-mercaptopurine therapy and thiopurine-methyl-transferase (TPMT) activity.

作者信息

McLeod H L

出版信息

Eur J Clin Pharmacol. 1995;48(1):85-8. doi: 10.1007/BF00202180.

DOI:10.1007/BF00202180
PMID:7621855
Abstract
摘要

相似文献

1
Commentary on interactions between 6-mercaptopurine therapy and thiopurine-methyl-transferase (TPMT) activity.6-巯基嘌呤治疗与硫嘌呤甲基转移酶（TPMT）活性之间相互作用的述评
Eur J Clin Pharmacol. 1995;48(1):85-8. doi: 10.1007/BF00202180.
2
Interactions between 6-mercaptopurine therapy and thiopurine-methyl-transferase (TPMT) activity.6-巯基嘌呤疗法与硫嘌呤甲基转移酶（TPMT）活性之间的相互作用。
Eur J Clin Pharmacol. 1994;46(4):385-6. doi: 10.1007/BF00194412.
3
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.先天性硫嘌呤甲基转移酶缺乏与急性淋巴细胞白血病治疗期间的6-巯基嘌呤毒性
Arch Dis Child. 1993 Nov;69(5):577-9. doi: 10.1136/adc.69.5.577.
4
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.巯嘌呤治疗不耐受与硫嘌呤S-甲基转移酶基因位点的杂合性
J Natl Cancer Inst. 1999 Dec 1;91(23):2001-8. doi: 10.1093/jnci/91.23.2001.
5
Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review.评估处方硫嘌呤类药物患者的硫嘌呤 S-甲基转移酶活性：系统评价。
Ann Intern Med. 2011 Jun 21;154(12):814-23, W-295-8. doi: 10.7326/0003-4819-154-12-201106210-00009.
6
Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine.柳氮磺胺吡啶对硫嘌呤甲基转移酶的抑制作用：与6-巯基嘌呤和硫唑嘌呤相互作用的可能机制。
Br J Clin Pharmacol. 1995 Apr;39(4):456-9. doi: 10.1111/j.1365-2125.1995.tb04478.x.
7
Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents.检测硫嘌呤甲基转移酶状态以安全有效地使用硫嘌呤：临床指南文件的系统评价
Pharmacogenomics J. 2014 Dec;14(6):493-502. doi: 10.1038/tpj.2014.47. Epub 2014 Aug 26.
8
Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism.6-巯基嘌呤对骨髓干细胞的潜在致癌作用：与硫嘌呤代谢的关系。
Cancer. 1999 Sep 15;86(6):1080-6. doi: 10.1002/(sici)1097-0142(19990915)86:6<1080::aid-cncr26>3.0.co;2-5.
9
Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.硫嘌呤类药物治疗儿童白血病：遗传性硫嘌呤甲基转移酶活性对药物代谢和细胞毒性的影响。
Br J Clin Pharmacol. 1997 Nov;44(5):455-61. doi: 10.1046/j.1365-2125.1997.t01-1-00607.x.
10
Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.接受硫唑嘌呤/6-巯基嘌呤治疗的患者中红细胞硫嘌呤核苷酸的液相色谱-串联质谱分析及硫嘌呤甲基转移酶基因变异对这些代谢物的影响
Clin Chem. 2005 Nov;51(11):2074-84. doi: 10.1373/clinchem.2005.050831. Epub 2005 Sep 15.

本文引用的文献

1
Variable mercaptopurine metabolism in children with leukaemia: a problem of non-compliance?白血病患儿中巯嘌呤代谢的个体差异：是治疗依从性问题吗？
BMJ. 1993 May 8;306(6887):1239-40. doi: 10.1136/bmj.306.6887.1239.
2
Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.硫嘌呤甲基转移酶缺乏的心脏移植受者中硫唑嘌呤诱导的骨髓抑制。
Lancet. 1993 May 1;341(8853):1151. doi: 10.1016/0140-6736(93)93168-z.
3
Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia.巯嘌呤代谢与儿童淋巴细胞白血病复发风险
Lancet. 1994 May 14;343(8907):1188-90. doi: 10.1016/s0140-6736(94)92400-7.
4
5-nucleotidase and azathioprine-related bone-marrow toxicity.
Lancet. 1993 Nov 13;342(8881):1245-6.
5
Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?口服巯嘌呤的生物利用度存在差异。急性淋巴细胞白血病的维持化疗是否得到了最佳实施？
N Engl J Med. 1983 Apr 28;308(17):1005-9. doi: 10.1056/NEJM198304283081705.
6
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia.儿童急性淋巴细胞白血病对6-巯基嘌呤反应的基因变异
Lancet. 1990 Jul 28;336(8709):225-9. doi: 10.1016/0140-6736(90)91745-v.
7
The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients.硫嘌呤甲基转移酶活性对于移植受者使用硫唑嘌呤的重要性。
Transplantation. 1992 May;53(5):1051-6. doi: 10.1097/00007890-199205000-00016.
8
The clinical pharmacology of 6-mercaptopurine.6-巯基嘌呤的临床药理学。
Eur J Clin Pharmacol. 1992;43(4):329-39. doi: 10.1007/BF02220605.