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人淋巴细胞钾-钠交换速率:协同吸附模型的预测

Rate of potassium-sodium exchange by human lymphocytes: prediction of the cooperative adsorption model.

作者信息

Negendank W, Karreman G

出版信息

J Cell Physiol. 1979 Jan;98(1):107-12. doi: 10.1002/jcp.1040980112.

DOI:10.1002/jcp.1040980112
PMID:762188
Abstract

The equilibrium parameters of potassium-sodium distribution in human lymphocytes, determined experimentally in the preceding study (Negendank and Shaller, '79), were incorporated into a stochastic treatment of the cooperative adsorption model in order to predict the kinetics of "active" potassium-sodium exchange. The rate of uptake of potassium, in potassium-depleted, sodium-loaded cells, is complex and deviates markedly from simple exponential functions. The sigmoid form of the exchange data closely followed the predicted curve. This result enhances one's confidence in the usefulness and applicability of the cooperative adsorption model, and adds further support to the association-induction hypothesis as a coherent theory of cell physiology.

摘要

在前一项研究(Negendank和Shaller,1979年)中通过实验测定的人体淋巴细胞中钾 - 钠分布的平衡参数,被纳入协同吸附模型的随机处理中,以预测“主动”钾 - 钠交换的动力学。在低钾、高钠的细胞中,钾的摄取速率很复杂,明显偏离简单的指数函数。交换数据的S形曲线与预测曲线紧密吻合。这一结果增强了人们对协同吸附模型的实用性和适用性的信心,并进一步支持了关联诱导假说作为细胞生理学的连贯理论。

相似文献

1
Rate of potassium-sodium exchange by human lymphocytes: prediction of the cooperative adsorption model.人淋巴细胞钾-钠交换速率:协同吸附模型的预测
J Cell Physiol. 1979 Jan;98(1):107-12. doi: 10.1002/jcp.1040980112.
2
Potassium-sodium distribution in human lymphocytes: description by the association-induction hypothesis.人类淋巴细胞中的钾钠分布:用缔合-诱导假说进行描述。
J Cell Physiol. 1979 Jan;98(1):95-105. doi: 10.1002/jcp.1040980111.
3
The physical state of potassium in the human lymphocyte: a review.人体淋巴细胞中钾的物理状态:综述
Scanning Microsc. 1989 Sep;3(3):865-72; discussion 872-5.
4
Fast and slow fractions of K+ flux in human lymphocytes.人类淋巴细胞中钾离子通量的快速和慢速组分
J Cell Physiol. 1979 Mar;98(3):539-52. doi: 10.1002/jcp.1040980312.
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Multiple fractions of sodium exchange in human lymphocytes.人类淋巴细胞中钠交换的多个组分
J Cell Physiol. 1980 Sep;104(3):443-59. doi: 10.1002/jcp.1041040317.
6
The effect of metabolic inhibition on ion contents and sodium exchange in human lymphocytes.代谢抑制对人淋巴细胞离子含量和钠交换的影响。
J Cell Physiol. 1982 Mar;110(3):291-9. doi: 10.1002/jcp.1041100312.
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A critical temperature transition of K+-Na+ exchange in human lymphocytes.人类淋巴细胞中钾离子-钠离子交换的临界温度转变
J Cell Physiol. 1980 Apr;103(1):87-95. doi: 10.1002/jcp.1041030113.
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[Changes in the content of potassium, sodium and potassium influx in human peripheral blood lymphocytes during long-term cultivation with phytohemagglutinin].
Tsitologiia. 1988 May;30(5):573-81.
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A cooperative transition theory applied to the kinetics of ionic exchanges in cells.一种应用于细胞中离子交换动力学的协同转变理论。
Cell Biophys. 1988 Oct;13(2):93-117. doi: 10.1007/BF02796974.
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Potasssium transport in human blood lymphocytes treated with phytohemagglutinin.用植物血凝素处理的人血淋巴细胞中的钾转运
J Clin Invest. 1976 Dec;58(6):1358-69. doi: 10.1172/JCI108591.

引用本文的文献

1
Self-exchange of sodium in human lymphocytes.人淋巴细胞中钠的自我交换
Biophys J. 1984 Sep;46(3):331-42. doi: 10.1016/S0006-3495(84)84029-1.
2
A cooperative transition theory applied to the kinetics of ionic exchanges in cells.一种应用于细胞中离子交换动力学的协同转变理论。
Cell Biophys. 1988 Oct;13(2):93-117. doi: 10.1007/BF02796974.