Melero J A
J Cell Physiol. 1979 Jan;98(1):17-30. doi: 10.1002/jcp.1040980104.
Mutants temperature-sensitive for growth have been isolated from the established line of Chinese hamster fibroblasts Wg1A. These mutants, together with the ones previously isolated by Roscoe et al. ('73), have been characterized with regard to their cell cycle properties. Most of them become arrested in the G1 phase of the cell cycle when incubated under restrictive conditions. By performing temperature shift experiments with synchronous cultures, the execution steps of most of the mutated functions have been located within the second half of the G1 phase.
已从中国仓鼠成纤维细胞Wg1A的既定细胞系中分离出对温度敏感的生长突变体。这些突变体与先前由罗斯科等人（1973年）分离出的突变体一起，已就其细胞周期特性进行了表征。当在限制条件下培养时，它们中的大多数在细胞周期的G1期停滞。通过对同步培养物进行温度转换实验，大多数突变功能的执行步骤已定位在G1期的后半段。
