外源性肿瘤坏死因子α和白细胞介素-1α可增强对鼠伤寒沙门氏菌的抵抗力：其疗效受Ity和Lps基因座的影响。
Exogenous tumor necrosis factor alpha and interleukin-1 alpha increase resistance to Salmonella typhimurium: efficacy is influenced by the Ity and Lps loci.
作者信息
Morrissey P J, Charrier K, Vogel S N
机构信息
Immunex Corporation, Seattle, Washington 98101, USA.
出版信息
Infect Immun. 1995 Aug;63(8):3196-8. doi: 10.1128/iai.63.8.3196-3198.1995.
Abstract
Interleukin-1 alpha (IL-1 alpha) or tumor necrosis factor alpha (TNF-alpha) administered prior to infection with Salmonella typhimurium increases survival in mice that are Ityr, not in susceptible Lpsd or Itys mice. Combined IL-1 alpha and TNF-alpha pretreatment results in greater survival than that seen with either cytokine alone in Ityr mice. Treatment after infection with TNF-alpha and/or IL-1 alpha increases the mean time to death but not the survival fraction of Lpsd mice and was ineffective in either Ityr or Itys mice.
摘要
在感染鼠伤寒沙门氏菌之前给予白细胞介素-1α（IL-1α）或肿瘤坏死因子α（TNF-α）可提高Ityr小鼠的存活率，但对易感的Lpsd或Itys小鼠无效。在Ityr小鼠中，联合使用IL-1α和TNF-α预处理后的存活率高于单独使用任何一种细胞因子。感染后用TNF-α和/或IL-1α治疗可延长Lpsd小鼠的平均死亡时间，但不能提高其存活比例，且对Ityr或Itys小鼠均无效。
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