Seed J R, Sechelski J
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599-7400, USA.
J Parasitol. 1995 Aug;81(4):653-7.
In crosses between 2 recombinant inbred strains of mice (B x H-2 and B x H-14), resistance to infection with Trypanosoma brucei rhodesiense as measured by survival time is suggested to be controlled by a dominant gene(s). In prior studies using the same clone of trypanosomes, but a different set of inbred mouse strains, it was demonstrated that resistance in H-2 congenic mice was a recessive trait. This work suggests that in mouse trypanosomiasis, the number of genes involved in resistance and their dominant or recessive nature will vary between different inbred mouse strains. There was a statistically significant difference between the survival times of animals with high or low antibody anti-trypanosome titers. Differences in survival time were not correlated with the height of the first parasitemia. There was, however, a strong negative correlation between the number of trypanosomes at the second peak in parasitemia and survival time. It is also suggested that the extent to which the host is immunosuppressed early in infection determines the ability to control the later peaks in parasitemia, and, therefore, survival time.
在两种重组近交系小鼠（B×H - 2和B×H - 14）的杂交实验中，通过存活时间衡量的对罗德西亚布氏锥虫感染的抗性被认为是由一个显性基因控制的。在之前使用同一克隆锥虫但不同近交系小鼠的研究中，已证明H - 2同源基因小鼠的抗性是隐性性状。这项工作表明，在小鼠锥虫病中，参与抗性的基因数量及其显性或隐性性质在不同近交系小鼠之间会有所不同。抗体抗锥虫滴度高或低的动物的存活时间存在统计学上的显著差异。存活时间的差异与首次寄生虫血症的高度无关。然而，寄生虫血症第二个峰值时的锥虫数量与存活时间之间存在很强的负相关。还表明，宿主在感染早期免疫抑制的程度决定了控制后期寄生虫血症峰值的能力，进而决定了存活时间。
