Fu Y, He F, Zhang S, Huang J, Zhang J, Jiao X
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
Neurotoxicol Teratol. 1995 May-Jun;17(3):333-9. doi: 10.1016/0892-0362(94)00076-p.
The mechanism of striatal damage induced by 3-nitropropionic acid (3-NPA) was studied in rats by neuropathological and neurochemical methods. Neuronal shrinkage with astrogliosis was observed in striatum after local injection of 0.5-5 mumol 3-NPA. Decortications involving dorsal and lateral aspects of frontal cortex or both frontal and parietal cortices significantly decreased the severity of striatal injuries induced by 3-NPA. This result suggests that corticostriatal projections play an important role in the development of striatal damage. No significant increase of glutamate and aspartate in striatal dialysates was observed, which indicated that 3-NPA may affect the postsynaptical sites and make the striatal neurons more vulnerable to endogenous levels of glutamate. Both of these findings suggested that 3-NPA produces indirect excitotoxic lesion to striatum. An increase of dopamine found in striatal dialysates may also be related to the occurrence of striatal damage.
采用神经病理学和神经化学方法，在大鼠中研究了3-硝基丙酸（3-NPA）诱导纹状体损伤的机制。局部注射0.5-5微摩尔3-NPA后，纹状体中观察到神经元萎缩伴星形胶质细胞增生。涉及额叶皮质背侧和外侧或额叶和顶叶皮质的去皮质显著降低了3-NPA诱导的纹状体损伤的严重程度。这一结果表明，皮质纹状体投射在纹状体损伤的发展中起重要作用。纹状体透析液中谷氨酸和天冬氨酸未显著增加，这表明3-NPA可能影响突触后位点，使纹状体神经元对内源性谷氨酸水平更敏感。这两个发现均提示，3-NPA对纹状体产生间接兴奋性毒性损伤。纹状体透析液中多巴胺的增加也可能与纹状体损伤的发生有关。
