Ehrenberg L, Törnqvist M
Department of Radiobiology, Stockholm University, Sweden.
Mutat Res. 1995 Aug;330(1-2):41-54. doi: 10.1016/0027-5107(95)00035-h.
Data for relationships between in vivo doses inferred from levels of hemoglobin (Hb) or DNA adducts and administered (by inhalation or injection) doses of ethylene oxide (EO) in mice, rats and humans are reviewed. At low absorbed doses or dose rates these relationships appear to be linear, whereas at higher dose rates deviations from linearity due to saturation kinetics of detoxification and of DNA repair as well as certain toxic effects have to be allowed for. If these factors are taken into consideration, a rather consistent picture is obtained for animal studies, with a variation by less than a factor 2 between estimates of adduct level increments or in vivo dose increments per unit of administered dose. Although the value for in vivo dose per unit of exposure dose (ppm-hour) in humans is uncertain because of unreliable data for the time-weighted average exposure level, the most likely value for this relationship, supported by data for ethene, agrees with data for the rodents. In the animal species testis doses are approximately one-half of the blood doses inferred from Hb adducts.
对从小鼠、大鼠和人类的血红蛋白（Hb）水平或DNA加合物推断出的体内剂量与经吸入或注射给予的环氧乙烷（EO）剂量之间的关系数据进行了综述。在低吸收剂量或剂量率下，这些关系似乎是线性的，而在较高剂量率下，由于解毒和DNA修复的饱和动力学以及某些毒性作用，必须考虑到与线性的偏差。如果考虑这些因素，动物研究可得到相当一致的结果，每单位给予剂量的加合物水平增量或体内剂量增量估计值之间的差异小于2倍。尽管由于时间加权平均暴露水平的数据不可靠，人类每单位暴露剂量（ppm-小时）的体内剂量值尚不确定，但乙烯数据支持的这种关系的最可能值与啮齿动物的数据一致。在动物物种中，睾丸剂量约为从Hb加合物推断出的血液剂量的一半。
