Adroer R, Santacruz P, Blesa R, López-Pousa S, Ascaso C, Oliva R
Human Genome and Molecular Genetics Research Group, Faculty of Medicine, University of Barcelona, Spain.
Neurosci Lett. 1995 Apr 21;189(3):182-6. doi: 10.1016/0304-3940(95)11480-k.
We have found an APOE epsilon 4 allelic frequency of 0.289 (95% CI 0.195-0.383) in Spanish AD patients (n = 88; average age = 71.2 +/- 9.37) and of 0.061 (95% CI 0.023-0.099) in age-matched controls (n = 147; average age = 71.5 +/- 10.29). Remarkably no ApoE 4/4 subjects were observed in any of the age-matched control groups compared to a total of 22 AD patients with the ApoE 4/4 phenotype. The combined odds ratio for subjects with one or two epsilon 4 alleles in the present study is 6.25 (95% CI 3.13-12.60), which is one of the highest so far reported. Altogether our results suggest a trans-European difference in the ApoE epsilon 4 frequency but no differences in the strength of the association between APOE4 and AD.
我们发现，西班牙阿尔茨海默病患者（n = 88；平均年龄 = 71.2 ± 9.37）中APOE ε4等位基因频率为0.289（95%置信区间0.195 - 0.383），年龄匹配的对照组（n = 147；平均年龄 = 71.5 ± 10.29）中该频率为0.061（95%置信区间0.023 - 0.099）。值得注意的是，在任何年龄匹配的对照组中均未观察到ApoE 4/4受试者，而共有22例阿尔茨海默病患者具有ApoE 4/4表型。本研究中携带一个或两个ε4等位基因的受试者的合并比值比为6.25（95%置信区间3.13 - 12.60），这是迄今为止报道的最高值之一。总体而言，我们的结果表明欧洲不同地区之间ApoE ε4频率存在差异，但APOE4与阿尔茨海默病之间关联强度无差异。
