Lu S F, Young H J, Lin M T
Department of Industrial Safety and Health, Chia-Nan Junior College of Pharmacy, Tainan, Taiwan, Republic of China.
Neurosci Lett. 1995 Apr 28;190(1):17-20. doi: 10.1016/0304-3940(95)11489-j.
Both sham-operated rats and rats with lesions of the nigrostriatal dopamine (DA) pathway were subjected to increasing or decreasing carotid sinus pressure (respectively produced by phenylephrine injection or bilateral carotid occlusion) and their striatal DA release and baroreflex responses were compared. In sham-operated rats, phenylephrine produced both increased striatal DA release and decreased heart rate, while bilateral carotid occlusion produced the opposite effects. Both the striatal DA release and baroreflex responses produced by phenylephrine or carotid occlusion were attenuated by lesions of the nigrostriatal DA pathway induced by intramedial forebrain bundle injection of 6-hydroxydopamine. The data indicate that the nigrostriatal DA pathway mediates baroreflex sensitivity in rats.
对假手术大鼠和黑质纹状体多巴胺（DA）通路损伤的大鼠分别进行颈动脉窦压力升高或降低（分别通过注射去氧肾上腺素或双侧颈动脉闭塞产生），并比较它们纹状体DA释放和压力感受性反射反应。在假手术大鼠中，去氧肾上腺素使纹状体DA释放增加且心率降低，而双侧颈动脉闭塞则产生相反的效果。由去氧肾上腺素或颈动脉闭塞所产生的纹状体DA释放和压力感受性反射反应，均因内侧前脑束注射6-羟基多巴胺诱导的黑质纹状体DA通路损伤而减弱。这些数据表明，黑质纹状体DA通路介导大鼠的压力感受性反射敏感性。
