Cohen I K, Crossland M C, Garrett A, Diegelmann R F
Wound Healing Center, Medical College of Virginia and Virginia Commonwealth University, Richmond, USA.
Plast Reconstr Surg. 1995 Aug;96(2):251-4. doi: 10.1097/00006534-199508000-00001.
Recent reports have suggested that human epidermal growth factor will accelerate the healing of corneal wounds and donor sites of burned patients undergoing split-thickness skin grafts. In one report using human epidermal growth factor in a silver sulfadiazine cream, these data were gathered from patients of various ages who had various depths of donor sites and degrees of burn. Therefore, despite the fact that these data were prospective, randomized, and double-blinded, we questioned the validity of the study. To test the hypothesis that topical application of human epidermal growth factor will enhance the healing of partial-thickness wounds, we utilized healthy volunteers (n = 17) and created bilateral split-thickness skin wounds (4 cm2) of the same depth (0.014 in) on each flank and then studied time until total epithelialization occurred. One side was treated with silver sulfadiazine as a control and the opposite side with silver sulfadiazine and human epidermal growth factor. There was no significant difference in the healing times between the human epidermal growth factor-treated sites and the silver sulfadiazine cream controls.
最近的报告表明，人表皮生长因子将加速角膜伤口的愈合以及接受中厚皮片移植的烧伤患者供皮区的愈合。在一份将人表皮生长因子用于磺胺嘧啶银乳膏的报告中，这些数据来自不同年龄、供皮区深度各异且烧伤程度不同的患者。因此，尽管这些数据是前瞻性、随机且双盲的，但我们对该研究的有效性提出质疑。为了验证局部应用人表皮生长因子会促进部分厚度伤口愈合这一假设，我们招募了健康志愿者（n = 17），在其双侧胁腹创建了深度相同（0.014英寸）的双侧中厚皮片伤口（4平方厘米），然后研究直至完全上皮化所需的时间。一侧用磺胺嘧啶银作为对照进行治疗，另一侧用磺胺嘧啶银和人表皮生长因子进行治疗。人表皮生长因子治疗部位与磺胺嘧啶银乳膏对照部位的愈合时间没有显著差异。
