阿尔茨海默型痴呆患者大脑皮质中内皮素-1样免疫反应性
Endothelin-1-like immunoreactivity in cerebral cortex of Alzheimer-type dementia.
作者信息
Minami M, Kimura M, Iwamoto N, Arai H
机构信息
Department of Psychiatry Juntendo University School of Medicine, Saitama, Japan.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1995 May;19(3):509-13. doi: 10.1016/0278-5846(95)00031-p.
PMID:7624501
Abstract
- Endothelin-1-like immunoreactivity (ET-1-LI) in cerebral cortex in postmortem brains obtained from patients with Alzheimer-type dementia (ATD) was measured by enzyme-immunoassay. 2. The ET-1-LI in the ATD brains was significantly increased in frontal and occipital cortex than those in the control brains and a significant correlation was found between frontal and temporal lobe of ATD brains. 3. These findings may explain the clinico-radiological results that the cerebral blood flow is decreased in ATD patients, the mechanism of which is still unknown.
摘要
- 采用酶免疫分析法测定了从阿尔茨海默病型痴呆（ATD）患者尸检大脑中获取的大脑皮质中的内皮素-1样免疫反应性（ET-1-LI）。2. ATD大脑额叶和枕叶皮质中的ET-1-LI显著高于对照大脑，并且在ATD大脑的额叶和颞叶之间发现了显著相关性。3. 这些发现可能解释了ATD患者脑血流量减少这一临床放射学结果，其机制尚不清楚。
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