Alcohol effects on hormone levels in normal postmenopausal women and in postmenopausal women with alcohol-induced cirrhosis.

The effects of alcoholic beverage consumption on the hormonal status of postmenopausal women will be reviewed. Focused attention on the effect of social drinking 244 normal postmenopausal women has revealed that moderate alcohol intake exerts a major influence not only on estradiol, testosterone, and the estimate of aromatization of testosterone to estradiol but also on the estrogen-responsive pituitary hormones in normal postmenopausal women. The hormonal status of 66 postmenopausal women with alcohol-induced cirrhosis is compared with normal alcohol-abstaining control women. As expected, there are significant differences in levels of all hormones; furthermore, hormonal interrelationships are also disrupted. Of major interest are findings that hormone levels in alcoholic cirrhotic postmenopausal women are related to the severity of liver disease. This observation supports a role for cirrhosis per se in the hormonal disruptions noted. Of further interest are findings that hormone levels may have prognostic value in postmenopausal women with alcohol-induced liver disease.