Funakoshi T, Ohta O, Shimada H, Kojima S
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Toxicol Lett. 1995 Aug;78(3):183-8. doi: 10.1016/0378-4274(95)03253-h.
The effects of N-benzyl-D-glucamine dithiocarbamate (BGD), diethyldithiocarbamate (DDTC), and N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD) on the enzymatic activities in mice were studied. The mice were given i.v. injections of these chelating agents (1 mmol/kg) and 3 h later the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (gamma-GTP), alkaline phosphatase (ALP), leucine aminopeptidase (LAP), and cholinesterase (ChE) in the liver, kidney, and blood were determined. These enzymatic activities were little changed by treatment with these chelating agents. Cadmium (Cd) administration markedly decreased the activities of AST and ALT in the liver and kidney and greatly increased these enzymatic activities in blood. The changes in the enzymatic activities by treatment with Cd were prevented by injection of BGD (1 mmol/kg). These results indicate that BGD, DDTC, and HBGD were not toxic to the liver or kidney of mice and that BGD treatment protected against the acute hepatic and renal toxicity induced by Cd.
研究了N-苄基-D-葡糖胺二硫代氨基甲酸盐（BGD）、二乙基二硫代氨基甲酸盐（DDTC）和N-对羟甲基苄基-D-葡糖胺二硫代氨基甲酸盐（HBGD）对小鼠酶活性的影响。给小鼠静脉注射这些螯合剂（1 mmol/kg），3小时后测定肝脏、肾脏和血液中天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、γ-谷氨酰转肽酶（γ-GTP）、碱性磷酸酶（ALP）、亮氨酸氨肽酶（LAP）和胆碱酯酶（ChE）的活性。这些螯合剂处理对这些酶活性影响不大。给予镉（Cd）显著降低了肝脏和肾脏中AST和ALT的活性，并大幅增加了血液中这些酶的活性。注射BGD（1 mmol/kg）可防止Cd处理引起的酶活性变化。这些结果表明，BGD、DDTC和HBGD对小鼠肝脏或肾脏无毒，且BGD处理可预防Cd诱导的急性肝毒性和肾毒性。
