Mize C E, Uauy R, Waidelich D, Neylan M J, Jacobs J
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75235-9063, USA.
Am J Clin Nutr. 1995 Aug;62(2):385-91. doi: 10.1093/ajcn/62.2.385.
To evaluate the effect of varying phosphorus intake with constant high calcium intake (430 micrograms/kJ, or 180 mg/100 kcal), we randomly assigned 35 appropriate-for-gestational-age healthy male infants (birth weight, 715-1510 g) on day 21 postnatally to either standard-phosphorus (215 micrograms/kJ, or 90 mg/100 kcal), moderate-phosphorus (254 micrograms/kJ, or 106 mg/100 kcal), or high-phosphorus intake (287 micrograms/kJ, or 120 mg/100 kcal). Three-day mineral balances were determined after 7 d of the study diets. Weight and head circumference gain and intake of energy and vitamin D were not different for all groups. Calcium retentions were sufficient to meet intrauterine accretion in all groups. Phosphorus calculated to be available for soft tissue was significantly higher in the moderate- and high-phosphorus groups, and was sufficient to support soft tissue phosphorus accretion in these two groups. Total absorbed phosphorus and phosphorus tubular reabsorption were each affected by phosphorus intake. We conclude that very low birth weight infants fed high calcium may require greater phosphorus intake than that provided by formulas containing a ratio of calcium to phosphorus of 2:1. We suggest that the optimal mass ratio of calcium to phosphorus for formula for very low birth weight infants is from 1.6:1 to 1.8:1.
为了评估在钙摄入量持续保持高水平（430微克/千焦，即180毫克/100千卡）的情况下，改变磷摄入量的影响，我们在出生后第21天将35名适于胎龄的健康男婴（出生体重715 - 1510克）随机分为标准磷摄入组（215微克/千焦，即90毫克/100千卡）、中等磷摄入组（254微克/千焦，即106毫克/100千卡）或高磷摄入组（287微克/千焦，即120毫克/100千卡）。在研究饮食7天后测定三天的矿物质平衡。所有组的体重和头围增长以及能量和维生素D的摄入量没有差异。所有组的钙潴留量足以满足宫内生长所需。计算得出的可用于软组织的磷在中等磷摄入组和高磷摄入组中显著更高，并且足以支持这两组软组织的磷增长。总吸收磷和磷肾小管重吸收均受磷摄入量的影响。我们得出结论，喂养高钙的极低出生体重婴儿可能需要比钙磷比为2:1的配方奶提供的磷摄入量更高。我们建议极低出生体重婴儿配方奶的最佳钙磷质量比为1.6:1至1.8:1。
