关于氟哌啶醇治疗精神病存在剂量反应阈值的进一步证据。
Further evidence of a dose-response threshold for haloperidol in psychosis.
作者信息
Stone C K, Garve D L, Griffith J, Hirschowitz J, Bennett J
机构信息
Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas, USA.
出版信息
Am J Psychiatry. 1995 Aug;152(8):1210-2. doi: 10.1176/ajp.152.8.1210.
OBJECTIVE
The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response.
METHOD
During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol.
RESULTS
No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected.
CONCLUSIONS
Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.
目的
作者的目标是确定更高剂量的氟哌啶醇是否能改善抗精神病反应。
方法
在一项为期2周的双盲、随机固定剂量研究中，24名精神病患者分别接受每日4毫克、10毫克或40毫克的氟哌啶醇治疗。
结果
未发现支持更高抗精神病药物剂量的组间临床相关差异。
结论
每日4毫克剂量的氟哌啶醇在治疗精神病方面似乎与更高剂量一样有效。
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