Boussinesq M, Chippaux J P, Ernould J C, Quillevere D, Prod'hon J
Antenne ORSTOM Aupres du Centre Pasteur du Cameroun, Yaounde.
Am J Trop Med Hyg. 1995 Jul;53(1):63-7.
Mass treatments with ivermectin have been undertaken each year since 1987 in an area hyperendemic for onchocerciasis in northern Cameroon. The impact of these successive treatments on the incidence of infection in humans was evaluated by comparing the prevalence of skin microfilariae (PMF) and the mean microfilarial skin densities (MFD) observed in 1987 and 1992 in 5-7-year-old children who had never taken the drug but who were members of the treated communities. In 1992, the PMF and the MFD in children in this age group who never received ivermectin were reduced by 55% and 77%, respectively, in comparison with the values observed in 1987, before the first treatment round. These results reflect a pronounced reduction in the intensity of the transmission of Onchocerca volvulus in the treatment zone. The influence of the ivermectin treatment coverage in the human population, as well as the vectorial capacity and the dispersal of the vector blackflies, on the transmission of onchocerciasis is discussed.
自1987年以来，喀麦隆北部盘尾丝虫病高度流行地区每年都开展伊维菌素群体治疗。通过比较1987年和1992年在从未服用过该药物但属于接受治疗社区的5至7岁儿童中观察到的皮肤微丝蚴患病率（PMF）和平均微丝蚴皮肤密度（MFD），评估了这些连续治疗对人类感染发病率的影响。1992年，与第一轮治疗前的1987年观察值相比，该年龄组从未接受伊维菌素治疗的儿童的PMF和MFD分别降低了55%和77%。这些结果反映出治疗区盘尾丝虫传播强度显著降低。文中讨论了人群中伊维菌素治疗覆盖率以及病媒黑蝇的媒介能力和扩散对盘尾丝虫病传播的影响。
