Phelps W C, Alexander K A
Burroughs Wellcome Co., Research Triangle Park, North Carolina, USA.
Ann Intern Med. 1995 Sep 1;123(5):368-82. doi: 10.7326/0003-4819-123-5-199509010-00008.
To review the basic virology of human papillomavirus (HPV) and the natural history of HPV infection and to discuss current and potential therapies.
The MEDLINE database (1966 to 1994) was searched to identify English-language articles and abstracts on HPV biology and antiviral chemotherapy.
Peer-reviewed basic science and clinical research studies on the molecular, cellular, and human biology of HPV infection.
Summaries of data from research studies on the biology of papillomavirus infection and information from review articles on the basic and applied pharmacology of antiviral agents.
Papillomavirus infections are very common. Human papillomavirus infections may be asymptomatic or may be manifested in various benign or malignant lesions, most notably anogenital condyloma and anogenital carcinoma. Currently, therapeutic options for HPV infection are limited, expensive, and often ineffective. By understanding the basic virology and natural history of HPV infection, potential sites for pharmacologic intervention can be identified. Although currently available antiviral compounds are inactive against HPV, they serve as models for the rational design of HPV antiviral drugs.
Although HPV infection causes substantial morbidity and expense, uniformly effective therapy for HPV infection is not currently available. Several processes in the HPV infection cycle are appropriate targets for the development of antiviral agents. The development of compounds active against HPV could prevent the benign and malignant diseases associated with HPV infection.
回顾人乳头瘤病毒（HPV）的基础病毒学及HPV感染的自然史，并讨论当前及潜在的治疗方法。
检索MEDLINE数据库（1966年至1994年），以识别关于HPV生物学及抗病毒化疗的英文文章和摘要。
关于HPV感染的分子、细胞及人体生物学的经同行评审的基础科学和临床研究。
乳头瘤病毒感染生物学研究的数据摘要，以及抗病毒药物基础和应用药理学综述文章中的信息。
乳头瘤病毒感染非常常见。人乳头瘤病毒感染可能无症状，或表现为各种良性或恶性病变，最显著的是肛门生殖器疣和肛门生殖器癌。目前，HPV感染的治疗选择有限、费用高昂且往往无效。通过了解HPV感染的基础病毒学和自然史，可以确定药物干预的潜在靶点。尽管目前可用的抗病毒化合物对HPV无活性，但它们可作为合理设计HPV抗病毒药物的模型。
尽管HPV感染会导致严重的发病率和费用，但目前尚无针对HPV感染的统一有效治疗方法。HPV感染周期中的几个过程是开发抗病毒药物的合适靶点。开发对HPV有活性的化合物可预防与HPV感染相关的良性和恶性疾病。
