de Beurs E, Lange A, van Dyck R, Koele P
Free University, Amsterdam, The Netherlands.
Aust N Z J Psychiatry. 1995 Mar;29(1):104-13. doi: 10.3109/00048679509075898.
Thirty-two patients suffering from panic disorder with agoraphobia were treated with repeated hyperventilation provocations and respiratory training, followed by exposure in vivo. The treatment was evaluated with a comprehensive set of outcome measures, including self-report questionnaires, a multitask behavioural avoidance test and continuous monitoring of panic. The treatment was found effective for the majority of patients in diminishing the frequency of panic attacks and agoraphobic avoidance. The clinical relevance of the treatment effect was evidenced by the considerable number of patients that recovered. The effect of the treatment was sustained over a three and six month follow-up period. The prognostic value of a number of variables for treatment outcome was also investigated. Three variables accounted for the majority of the variance in treatment outcome: a higher pretreatment level of agoraphobic complaints, use of psychotropic medication and a longer duration of the disorder were associated with poorer outcome. Other variables, such as the therapeutic relationship and the quality of the marital bond, had no prognostic value.
32名患有广场恐怖症的惊恐障碍患者接受了反复的过度换气激发试验和呼吸训练，随后进行现场暴露治疗。采用一套全面的结果测量方法对治疗进行评估，包括自我报告问卷、多任务行为回避测试和惊恐发作的持续监测。结果发现，该治疗方法对大多数患者减少惊恐发作频率和广场恐怖回避行为有效。大量患者康复证明了治疗效果的临床相关性。治疗效果在3个月和6个月的随访期内得以维持。还研究了一些变量对治疗结果的预后价值。三个变量占治疗结果差异的大部分：广场恐怖症抱怨的预处理水平较高、使用精神药物以及疾病持续时间较长与较差的结果相关。其他变量，如治疗关系和婚姻关系质量，没有预后价值。
