Atten M J, Attar B M, Holian O
Department of Medicine, Cook County Hospital, Chicago, IL 60612, USA.
Biochem Biophys Res Commun. 1995 Jul 26;212(3):1001-6. doi: 10.1006/bbrc.1995.2069.
We investigated the cellular signaling events involved in gastric cancer by examining the role of mitogen activated protein kinase (MAPK) in normal and transformed human gastric tissue. A significant loss in both MAPK abundance and activity was found in the membrane fractions of the adenocarcinomas when compared to the histologically normal gastric tissue, while no significant alteration in MAPK was seen in the cytosolic fractions from these two tissue types. These findings suggest that reduction in MAPK abundance and activity are associated with loss of normal growth control in human gastric adenocarcinoma.
我们通过研究丝裂原活化蛋白激酶（MAPK）在正常和转化的人胃组织中的作用，来探究参与胃癌发生的细胞信号转导事件。与组织学上正常的胃组织相比，在腺癌的膜组分中发现MAPK丰度和活性均显著降低，而在这两种组织类型的胞质组分中未观察到MAPK有明显改变。这些发现表明，MAPK丰度和活性的降低与人类胃腺癌中正常生长控制的丧失有关。
