Palma-Carlos A G, Palma-Carlos M L, Santos M C, Melo A
Centro de Hematologia e Imunologia, Faculdade de Medicina de Lisboa, Portugal.
Allerg Immunol (Paris). 1995 Jun;27(6):178-81.
Cytokines and adhesion molecules play a central role in the inflammatory process of respiratory allergy. Cytokines like IL4 acts on IgE synthesis and expression of low affinity CD23 IgE receptors, IL-5 on eosinophil differentiation and activation and IL-2 on T cell activation and on the expression of CD25 IL-2 receptors. IL-2, IL-4 and IL-2 soluble receptor have been studied in pollen sensitive patients before, during and after pollen season. IL-2 serum levels initially increase and decrease at the end of allergen exposition. IL-4 serum level do not significantly changes during pollen season. Adhesion molecules are essential for recruitment and migration of inflammatory cells to tissues. CD45RO T memory cells expressing generally the adhesion molecule CD29 have also been studied in a group of pollen sensitive patients. During the peak of antigen exposition CD45RO/CD29 cells significantly decrease a turnover between CD45RA naive cells and memory cells being observed. The study of cytokines and adhesion molecules could add new data on the comprehension of inflammation in respiratory allergy.
细胞因子和黏附分子在呼吸道过敏的炎症过程中起核心作用。细胞因子如白细胞介素-4（IL-4）作用于免疫球蛋白E（IgE）的合成及低亲和力IgE受体CD23的表达，白细胞介素-5（IL-5）作用于嗜酸性粒细胞的分化和激活，白细胞介素-2（IL-2）作用于T细胞激活及白细胞介素-2受体CD25的表达。白细胞介素-2、白细胞介素-4及白细胞介素-2可溶性受体已在花粉敏感患者的花粉季节前、期间及之后进行了研究。白细胞介素-2血清水平在变应原暴露开始时升高，在暴露结束时降低。在花粉季节期间，白细胞介素-4血清水平无显著变化。黏附分子对于炎性细胞向组织的募集和迁移至关重要。一组花粉敏感患者也对通常表达黏附分子CD29的CD45RO T记忆细胞进行了研究。在抗原暴露高峰期，CD45RO/CD29细胞显著减少，观察到CD45RA初始细胞和记忆细胞之间的转换。对细胞因子和黏附分子的研究可为理解呼吸道过敏中的炎症增加新的数据。
