通过紫外共振拉曼光谱研究嵌入型抗癌药物与DNA之间的相互作用。
Interaction between intercalation type anticancer drugs and DNA studied by ultraviolet resonance Raman spectroscopy.
作者信息
Zhao X, Lu D, Jiang S, Mao C, Fan Y, An C, Li Z
机构信息
State Key Laboratory of Laser Technology, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Sci China B. 1995 May;38(5):555-63.
The interaction of typical intercalation type anticancer drugs, adriamycin (ADM) and aclacinomycin (ACM), with calf thymus DNA was studied first with ultraviolet resonance Raman spectroscopy (UVRRS). The results demonstrate that the important information such as intercalation sites of drugs, the electronic interaction and the hydrogen bonds between drugs and DNA can be obtained by UVRRS. The method can also show the influence of drugs on DNA conformation and hydrogen bonds between bases of DNA.
首先利用紫外共振拉曼光谱（UVRRS）研究了典型的嵌入型抗癌药物阿霉素（ADM）和阿克拉霉素（ACM）与小牛胸腺DNA的相互作用。结果表明，通过UVRRS可以获得诸如药物的嵌入位点、药物与DNA之间的电子相互作用以及氢键等重要信息。该方法还可以显示药物对DNA构象以及DNA碱基之间氢键的影响。
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