从牛成牙本质细胞文库中克隆牛Msx-1含同源框基因cDNA及其序列

Molecular cloning and sequence of bovine Msx-1 homeobox-containing gene cDNA from a bovine odontoblast library.

作者信息

Iimura T, Oida S, Takeda K, Maruoka Y, Shimokawa H, Ibaraki K, Sasaki S

机构信息

Department of Biochemistry, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.

出版信息

DNA Seq. 1995;5(4):233-7. doi: 10.3109/10425179509030972.

DOI:10.3109/10425179509030972

PMID:7626784

Abstract

Screening of a bovine odontoblast cDNA library from developing incisor with murine Msx-1 and Msx-2 cDNA probes led to the isolation of three positive clones. All of them encoded for a sequence of a protein containing 297 amino acids. The responsible gene was designated as bovine Msx-1 (bMsx-1) due to the high homology with the human MSX-1 and mouse Msx-1 sequences.

摘要

用小鼠Msx-1和Msx-2 cDNA探针筛选发育中切牙的牛成牙本质细胞cDNA文库，分离出三个阳性克隆。它们都编码一个含有297个氨基酸的蛋白质序列。由于与人类MSX-1和小鼠Msx-1序列高度同源，该相关基因被命名为牛Msx-1（bMsx-1）。