Lyketsos C G, Kraus M
Neuropsychiatry and Memory Group, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Neuropsychiatry Clin Neurosci. 1995 Spring;7(2):239-42. doi: 10.1176/jnp.7.2.239.
Two cases of Gerstmann-Sträussler-Scheinker syndrome (GSS) are discussed in detail. These cases illustrate the variable clinical course and mostly cortical features of GSS-associated dementia. Given the availability of genetic tests that can now diagnose GSS, clinicians should consider these tests in cases where patients with dementia have extensive family histories or if the clinical course is atypical for Alzheimer's or vascular dementia.
详细讨论了两例格斯特曼-施特劳斯勒-谢inker综合征（GSS）。这些病例说明了GSS相关痴呆的临床病程多变以及主要的皮质特征。鉴于现在有可用于诊断GSS的基因检测，对于有广泛家族病史的痴呆患者或临床病程不符合阿尔茨海默病或血管性痴呆典型表现的病例，临床医生应考虑进行这些检测。
