Buzan R D, Dubovsky S L, Treadway J T, Thomas M
University of Colorado Health Sciences Center in Denver, USA.
Psychiatr Serv. 1995 May;46(5):511-2. doi: 10.1176/ps.46.5.511.
Opiate antagonists have shown promise for treating a subset of self injurious patients. The authors report on the use of naltrexone with three mentally retarded adults who had long histories of self-injurious behavior and unsuccessful behavioral and drug treatments; for all three, the self- injurious behavior was substantially decreased. The authors have found a positive response for half the self-injurious patients for whom naltrexone has been tried. Before any drug therapy is initiated, environmental reinforcers of the behavior should be sought out and modified, and any reversible medical and psychiatric disorders should be treated.
阿片类拮抗剂已显示出治疗一部分自伤患者的前景。作者报告了对三名患有长期自伤行为且行为和药物治疗均未成功的成年智障患者使用纳曲酮的情况；对这三名患者而言，自伤行为均大幅减少。作者发现，在尝试使用纳曲酮治疗的自伤患者中，有一半获得了积极反应。在开始任何药物治疗之前，应找出并改变该行为的环境强化因素，同时应对任何可逆转的医学和精神疾病进行治疗。
