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Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?

作者信息

Hume D A, Favot P

机构信息

Centre for Molecular and Cellular Biology, University of Queensland, Australia.

出版信息

J Interferon Cytokine Res. 1995 Apr;15(4):279-84. doi: 10.1089/jir.1995.15.279.

DOI:10.1089/jir.1995.15.279
PMID:7627801
Abstract

The op/op mouse has a mutation in the macrophage colony-stimulating (CSF-1) gene. The phenotype of gross deficiency in the macrophage and osteoclast lineages corrects significantly with age, suggesting that other factors can substitute for CSF-1. This review examines the evidence that the op/op mouse is completely CSF-1 deficient and considers the possibility that alternative splicing within the CSF-1 gene might bypass the mutation, yielding an incompletely penetrant phenotype.

摘要

相似文献

1
Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?
J Interferon Cytokine Res. 1995 Apr;15(4):279-84. doi: 10.1089/jir.1995.15.279.
2
Granulocyte-macrophage colony-stimulating factor is not responsible for the correction of hematopoietic deficiencies in the maturing op/op mouse.粒细胞-巨噬细胞集落刺激因子对成熟的op/op小鼠造血缺陷的纠正不起作用。
Blood. 1995 Jul 1;86(1):66-72.
3
Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation.骨硬化症（op/op）小鼠中破骨细胞的新生变化，该小鼠在功能性巨噬细胞集落刺激因子（M-CSF）蛋白产生方面存在缺陷，以及M-CSF对破骨细胞发育和分化的影响。
J Submicrosc Cytol Pathol. 1996 Jan;28(1):13-26.
4
Heterogeneity of colony stimulating factor-1 gene expression in the skeleton of four osteopetrotic mutations in rats and mice.大鼠和小鼠四种骨石化突变体骨骼中集落刺激因子-1基因表达的异质性。
J Cell Physiol. 1996 Feb;166(2):340-50. doi: 10.1002/(SICI)1097-4652(199602)166:2<340::AID-JCP12>3.0.CO;2-F.
5
Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity.缺乏巨噬细胞集落刺激因子（M-CSF/CSF-1）活性的骨硬化（op）突变小鼠中巨噬细胞和树突状细胞的超微结构
J Submicrosc Cytol Pathol. 1994 Jan;26(1):111-9.
6
Macrophage differentiation and granulomatous inflammation in osteopetrotic mice (op/op) defective in the production of CSF-1.在缺乏集落刺激因子-1（CSF-1）产生的石骨症小鼠（op/op）中的巨噬细胞分化和肉芽肿性炎症。
Mol Reprod Dev. 1997 Jan;46(1):85-91. doi: 10.1002/(SICI)1098-2795(199701)46:1<85::AID-MRD13>3.0.CO;2-2.
7
CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages.op/op小鼠中的集落刺激因子1缺乏对巨噬细胞群体和分化阶段有不同影响。
Exp Hematol. 1992 Sep;20(8):1004-10.
8
Relative roles of osteoclast colony-stimulating factor and macrophage colony-stimulating factor in the course of osteoclast development.破骨细胞集落刺激因子和巨噬细胞集落刺激因子在破骨细胞发育过程中的相对作用。
Exp Hematol. 1994 Jan;22(1):66-73.
9
Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption.血管内皮生长因子可替代巨噬细胞集落刺激因子，以支持破骨细胞的骨吸收。
J Exp Med. 1999 Jul 19;190(2):293-8. doi: 10.1084/jem.190.2.293.
10
In vivo role of macrophage growth factors as delineated using CSF-1 deficient op/op mouse.利用集落刺激因子-1（CSF-1）缺陷的op/op小鼠所阐明的巨噬细胞生长因子的体内作用。
Leukemia. 1993 Aug;7 Suppl 2:S117-21.

引用本文的文献

1
Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects.Meox2Cre 介导的 CSF-1 缺失导致骨质硬化症和骨细胞缺陷。
Bone. 2012 Jan;50(1):42-53. doi: 10.1016/j.bone.2011.09.038. Epub 2011 Sep 20.
2
Langerhans cells arise from monocytes in vivo.朗格汉斯细胞在体内由单核细胞产生。
Nat Immunol. 2006 Mar;7(3):265-73. doi: 10.1038/ni1307. Epub 2006 Jan 29.
3
The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification.
骨石化突变体无牙（tl）是大鼠Csf1基因中的功能丧失型移码突变：CSF-1在破骨细胞生成和软骨内骨化中起关键作用的证据。
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14303-8. doi: 10.1073/pnas.202332999. Epub 2002 Oct 11.