Chan J C, DeLuca H R
JAMA. 1979 Mar 23;241(12):1242-4.
Progression of renal failure, represented by rising serum creatinine concentrations, was correlated with progressive elevation of serum parathyroid hormone (PTH) concentrations in 23 children. A significant linear relationship was established. Despite normal serum calcium concentrations in 11 children receiving maintenance hemodialysis, circulating PTH concentrations were elevated after six months. Progressive deterioration with time occurred in all variables tested, at six-month intervals. These complications were reversible with kidney transplantation or treatment with 0.25 to 2 microgram/day of calcitriol for four to 20 weeks.
23名儿童中，以血清肌酐浓度升高为代表的肾衰竭进展与血清甲状旁腺激素（PTH）浓度的逐渐升高相关。建立了显著的线性关系。11名接受维持性血液透析的儿童血清钙浓度正常，但6个月后循环PTH浓度升高。每隔6个月对所有测试变量进行检测，发现随着时间推移均出现进行性恶化。这些并发症通过肾移植或每天使用0.25至2微克骨化三醇治疗4至20周后可逆转。
