Shehadeh I H, Demers L M, Abt A B, Schoolwerth A C
JAMA. 1979 Mar 23;241(12):1264-6.
Treatment of membranous nephropathy and the nephrotic syndrome with 2 mg/kg/day of indomethacin resulted in prompt and sustained reduction in urinary protein excretion and the loss of edema fluid, which allowed the withdrawal of diuretic therapy and liberalization of salt intake. The reduction in proteinuria was paralleled by a decrease in urinary prostaglandin E (PGE) and F (PGF) levels. Plasma PGE and PGF levels did not change appreciably. Withdrawal of indomethacin therapy resulted in an increase in urinary protein and urinary PGE excretion. Reinstitution of therapy resulted in reductions in both values. Indomethacin may provide a useful means of reducing proteinuria and controlling edema in some patients with the nephrotic syndrome.
以每日2毫克/千克的消炎痛治疗膜性肾病和肾病综合征，可迅速且持续地减少尿蛋白排泄，并使水肿液消退，从而得以停用利尿剂治疗并放宽盐的摄入量。蛋白尿的减少与尿前列腺素E（PGE）和前列腺素F（PGF）水平的降低同时出现。血浆PGE和PGF水平无明显变化。停用消炎痛治疗会导致尿蛋白和尿PGE排泄增加。重新开始治疗则会使两者的值均降低。对于一些肾病综合征患者，消炎痛可能是减少蛋白尿和控制水肿的有效方法。
