Ragheb A M, Elgazzar A H, Ibrahim A K, Higazi E, Mahmoud A R, el-Saleh K, Omar Y T, Abdel-Dayem H M
Kuwait Cancer Control Center (KCCC), Ministry of Public Health.
Clin Nucl Med. 1995 May;20(5):426-33. doi: 10.1097/00003072-199505000-00011.
Seventy patients with newly diagnosed, pathologically proven inoperable non-small cell lung cancer (NSCLC) had planar Ga-67, Tl-201, chest x-ray, and chest CT imaging performed. Tumor/Normal tissue background (T/B) ratio was calculated for 62 Ga-67 and 55 Tl-201 scintigraphy studies and comparisons were made between Ga-67 and Tl-201 imaging results regarding T/B ratios, site of lesion, and histologic type. The impact of the images on the initial knowledge of the extent of the tumor and on the radiotherapy (RT) planning was evaluated for each patient. For primary lesions, Ga-67 imaging results were positive in 94% (66 of 70 patients) versus 71% (50 of 70 patients) for Tl-201 scans (P < 0.005) and the T/B ratio was > 1.5 in 74% (46 of 62 patients) for Ga-67 versus 36% (20 of 55 patients) for Tl-201 (P < 0.0001). For centrally located lesions, sensitivity for Ga-67 was 100% (53 of 53 patients) versus 74% (39 of 53 patients) for Tl-201 (P < 0.0005) and the T/B ratio > 1.5 in 84% (38 of 45 patients) for Ga-67 versus 38% (15 of 40 patients) for Tl-201 (P > 0.001). For peripheral lesions, sensitivity of Ga-67 was 76% (13 of 17 patients) versus 64% (11 of 17) for Tl-201 (P > 0.05) and the T/B ratio was > 1.5 in 47% (8 of 17 patients) for Ga-67 versus 33% (5 of 15 patients) for Tl-201 (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
70例新诊断、经病理证实为不可切除的非小细胞肺癌（NSCLC）患者接受了平面Ga-67、Tl-201、胸部X线及胸部CT成像检查。对62例Ga-67和55例Tl-201闪烁扫描研究计算了肿瘤/正常组织本底（T/B）比值，并就T/B比值、病变部位及组织学类型对Ga-67和Tl-201成像结果进行了比较。评估了每位患者的图像对肿瘤范围初步认知及放射治疗（RT）计划的影响。对于原发性病变，Ga-67成像结果阳性率为94%（70例患者中的66例），而Tl-201扫描为71%（70例患者中的50例）（P<0.005），Ga-67的T/B比值>1.5的患者占74%（62例患者中的46例），而Tl-201为36%（55例患者中的20例）（P<0.0001）。对于中央型病变，Ga-67的敏感性为100%（53例患者中的53例），而Tl-201为74%（53例患者中的39例）（P<0.0005），Ga-67的T/B比值>1.5的患者占84%（45例患者中的38例），而Tl-201为38%（40例患者中的15例）（P>0.001）。对于周围型病变，Ga-67的敏感性为76%（17例患者中的13例），而Tl-201为64%（17例患者中的11例）（P>0.05），Ga-67的T/B比值>1.5的患者占47%（17例患者中的8例），而Tl-201为33%（15例患者中的5例）（P<0.05）。（摘要截断于250字）
