Miron S D, Finkelhor R, Bahler R, Sodee D B, Bellon E M
Department of Radiology, MetroHealth Medical Center, Cleveland, OH 44109-1998, USA.
Clin Nucl Med. 1995 May;20(5):440-5. doi: 10.1097/00003072-199505000-00014.
To evaluate whether a prolonged infusion of Tc-99m sestamibi allows for visualization of viable myocardium in areas of hypoperfused myocardium, 25 patients were prospectively studied. Each patient was imaged four times in two consecutive days in the following manner: day 1:1) immediately after injection of Tl-201 at rest, 2) 1 hour after a bolus injection of Tc-99m sestamibi at rest; and day 2: 1) imaging in the Tl-201 window for 24 hour redistribution, 2) imaging after a 1-hour infusion of Tc-99m sestamibi. The two Tc-99m sestamibi and two Tl-201 studies were evaluated for presence of redistribution. This was present both on the Tl-201 and Tc-99m sestamibi studies (concordant) in 13 cases, and absent on both the Tl-201 and Tc-99m sestamibi studies (concordant) in 9 cases. In two cases redistribution was seen on the Tl-201 images only, and in one case it was seen on the Tc-99m sestamibi images only (discordant). Tc-99m sestamibi infusion may provide information about the presence of viable myocardium which is similar to that provided by Tl-201 24-hour imaging.
为评估延长注射锝-99m甲氧基异丁基异腈（Tc-99m sestamibi）是否能使灌注不足心肌区域的存活心肌显影，对25例患者进行了前瞻性研究。每位患者在连续两天内进行4次成像，方式如下：第1天：1）静息状态下注射铊-201（Tl-201）后立即成像；2）静息状态下静脉推注Tc-99m sestamibi 1小时后成像。第2天：1）在Tl-201能窗进行24小时再分布成像；2）静脉输注Tc-99m sestamibi 1小时后成像。对两次Tc-99m sestamibi和两次Tl-201检查评估再分布情况。13例患者的Tl-201和Tc-99m sestamibi检查均出现再分布（一致），9例患者的Tl-201和Tc-99m sestamibi检查均未出现再分布（一致）。2例患者仅在Tl-201图像上出现再分布，1例患者仅在Tc-99m sestamibi图像上出现再分布（不一致）。静脉输注Tc-99m sestamibi可能提供与Tl-201 24小时成像相似的关于存活心肌存在情况的信息。
