Polito C, La Manna A, Todisco N, Cimmaruta E, Sessa G, Pirozzi M
Department of Pediatrics, Second University of Naples, Italy.
Clin Pediatr (Phila). 1995 May;34(5):234-6. doi: 10.1177/000992289503400501.
Bone mineral content (BMC) was measured by single-photon absorptiometry in 24 children with steroid-dependent, minimal-lesion nephrotic syndrome after 1 to 6.3 years of alternate-day prednisone therapy and in a sex- and age-matched control group. Bone mineral content was -0.002 +/- 1.2 standard deviation scores in patients and 0.3 +/- 1.4 in controls (t = 1.17; P = 0.25). No significant relation was found between BMC in patients and the amount of prednisone taken or the duration of therapy. Alternate-day prednisone therapy at doses usually needed to keep children with steroid-dependent nephrotic syndrome under control does not significantly affect BMC.
采用单光子吸收法对24例依赖类固醇的微小病变型肾病综合征患儿进行骨矿物质含量（BMC）测量，这些患儿接受了1至6.3年的隔日泼尼松治疗，并与性别和年龄匹配的对照组进行比较。患者的骨矿物质含量为-0.002±1.2标准差分数，对照组为0.3±1.4（t=1.17；P=0.25）。未发现患者的骨矿物质含量与泼尼松服用量或治疗持续时间之间存在显著关联。以通常用于控制依赖类固醇肾病综合征患儿的剂量进行隔日泼尼松治疗，对骨矿物质含量无显著影响。
