Vargas J A, Alvarez-Mon M, Manzano L, Albillos A, Fernández-Corugedo A, Gea-Banacloche J C, Gonzalez F M, Durántez A
Service of Internal Medicine I, Clínica Puerta de Hierro, Universidad Autónoma, Madrid, Spain.
Dig Dis Sci. 1995 Jul;40(7):1538-41. doi: 10.1007/BF02285205.
Patients with pernicious anemia have an estimated risk of gastric adenocarcinoma that ranges from three- to fivefold greater than that of the general population. It has been reported that NK cells may be involved in immunosurveillance against tumor spread. The natural killer cell activity of peripheral blood mononuclear cells was analyzed in 22 patients with pernicious anemia and in 19 healthy controls. Levels of natural killer cell activity against K-562 target cells were similar in control subjects and patients, regardless of gastrin levels and time elapsed since diagnosis. According to quantitative flow cytometry analysis, similar percentages of phenotypically defined NK cells (CD16+) were found in peripheral blood mononuclear cells from patients and healthy controls. Our results show that in pernicious anemia patients, the percentage of NK cells present in peripheral blood mononuclear cells and their lytic activity are normal.
恶性贫血患者患胃腺癌的估计风险比普通人群高两到四倍。据报道，自然杀伤细胞（NK细胞）可能参与针对肿瘤扩散的免疫监视。对22例恶性贫血患者和19例健康对照者的外周血单个核细胞的自然杀伤细胞活性进行了分析。无论胃泌素水平和诊断后经过的时间如何，对照受试者和患者中针对K-562靶细胞的自然杀伤细胞活性水平相似。根据定量流式细胞术分析，在患者和健康对照者的外周血单个核细胞中发现表型定义的NK细胞（CD16+）的百分比相似。我们的结果表明，在恶性贫血患者中，外周血单个核细胞中NK细胞的百分比及其裂解活性是正常的。
