Kempczinski R F
JAMA. 1979 Feb 23;241(8):807-10.
Ten cases of lower-extremity emboli originated from proximal, ulcerated atherosclerotic plaques. Two distinct clinical presentations were seen. Embolization of cholesterol-rich debris was usually widespread and lodged in terminal arteries, producing either focal digital ischemia or livedo reticularis of the extremity. By contrast, thrombi arising from mural erosions were larger and produced a picture indistinguishable from emboli of cardiac origin. Biplanar aortography was essential in making the correct diagnosis. Anticoagulation has not prevented recurrent embolization. Endarterectomy or graft replacement of the diseased arterial segment is the preferred method of treatment. Lumbar sympathectomy is a useful adjunct when persistent cutaneous ischemia is present.
10例下肢栓子起源于近端溃疡性动脉粥样硬化斑块。出现了两种不同的临床表现。富含胆固醇碎片的栓子通常广泛分布并栓塞于终末动脉,导致局限性手指缺血或肢体网状青斑。相比之下,由壁层糜烂形成的血栓较大,其表现与心脏来源的栓子难以区分。双平面主动脉造影对做出正确诊断至关重要。抗凝治疗未能预防复发性栓塞。病变动脉段的内膜切除术或血管移植置换术是首选的治疗方法。当存在持续性皮肤缺血时,腰交感神经切除术是一种有效的辅助治疗方法。