[Effects of polychlorinated biphenyls (PCBs) on porphyrin metabolism--experimental porphyria induced by large single doses of PCBs].

The effects of large single doses of PCBs and iron overload on porphyrin metabolism were investigated in male C57BL/6 mice. A single intraperitoneal dose of Kanechlor-500 (10 mg/mouse) caused urinary uroporphyrin to increase three days after injection. This increase was transient without porphyrin accumulation in the liver. Iron overload (12.5 mg/mouse) showed a tendency to prolong the action of PCBs.