[Effects of polychlorinated biphenyls (PCBs) on porphyrin metabolism--experimental porphyria induced by large single doses of PCBs].
作者信息
Tsukazaki N, Yoshida H, Irifune H, Watanabe M, Tanaka K
机构信息
Department of Dermatology, Nagasaki University School of Medicine.
出版信息
Fukuoka Igaku Zasshi. 1995 May;86(5):207-11.
PMID:7628810
Abstract
The effects of large single doses of PCBs and iron overload on porphyrin metabolism were investigated in male C57BL/6 mice. A single intraperitoneal dose of Kanechlor-500 (10 mg/mouse) caused urinary uroporphyrin to increase three days after injection. This increase was transient without porphyrin accumulation in the liver. Iron overload (12.5 mg/mouse) showed a tendency to prolong the action of PCBs.
摘要
Zotero 插件