在哮喘患者乙酰甲胆碱激发试验期间，通过同时评估第一秒用力呼气容积（FEV1）和经皮氧分压变化所获得的剂量-反应斜率的比较。

Comparison of dose-response slopes obtained by simultaneous assessment of changes in FEV1 and transcutaneous oxygen partial pressure during methacholine challenges in asthmatic patients.

作者信息

Fontana G A, Lavorini F, Boddi V, Camiciottoli G, Panuccio P

机构信息

Dipartimento di Fisiopatologia Clinica, Università di Firenze, Florence, Italy.

出版信息

J Asthma. 1995;32(4):301-7. doi: 10.3109/02770909509044838.

DOI:10.3109/02770909509044838

PMID:7629006

Abstract

We aimed to ascertain whether monitoring changes in transcutaneous (tc) oxygen partial pressure (PO2) may be used to determine the slope of the dose-response curves to inhaled methacholine. In 10 adult asthmatic patients, FEV1 and tcPO2 were simultaneously measured during inhalation of doubling methacholine concentrations. In each patient, the slopes of the methacholine dose-response curves for FEV1 and tcPO2 were similar and strongly correlated (r = 0.72; p < 0.05). The results indicate that tcPO2 monitoring represents a useful, reliable tool for analysis of the slope of dose-response curves to inhaled methacholine in asthmatic patients. It can also be used to investigate the pathophysiological implications of bronchial hyperreactivity.

摘要

我们旨在确定监测经皮（tc）氧分压（PO2）的变化是否可用于确定吸入乙酰甲胆碱的剂量反应曲线斜率。在10名成年哮喘患者中，在吸入双倍浓度乙酰甲胆碱期间同时测量FEV1和tcPO2。在每位患者中，FEV1和tcPO2的乙酰甲胆碱剂量反应曲线斜率相似且相关性很强（r = 0.72；p < 0.05）。结果表明，tcPO2监测是分析哮喘患者吸入乙酰甲胆碱剂量反应曲线斜率的一种有用且可靠的工具。它还可用于研究支气管高反应性的病理生理意义。