Perry R R, Vinik A I
Diabetes Institutes, Eastern Virginia Medical School, Norfolk 23510, USA.
J Clin Endocrinol Metab. 1995 Aug;80(8):2273-8. doi: 10.1210/jcem.80.8.7629220.
Functional islet cell tumors cause recognizable clinical syndromes based on the peptide products they secrete (Table 1). Frequently, the diagnosis of these tumors is delayed. A high index of suspicion coupled with the use of appropriate biochemical and provocative tests should lead to earlier diagnosis. A suggested management plan for patients suspected of having an islet cell tumor is shown in Fig. 1. Earlier diagnosis coupled with advances in preoperative and intraoperative localization techniques have resulted in an increased number of patients being cured.
功能性胰岛细胞瘤根据其分泌的肽类产物引起可识别的临床综合征（表1）。这些肿瘤的诊断常常延迟。高度的怀疑指数加上使用适当的生化和激发试验应能实现更早的诊断。图1展示了针对疑似患有胰岛细胞瘤患者的建议管理方案。更早的诊断加上术前和术中定位技术的进步，已使治愈的患者数量增加。
