Cazzola M, Santangelo G, Angrisani M, Vinciguerra A, Contaldi C, Rossi F
Institute of Pharmacology and Toxicology, Medical School, II University, Naples, Italy.
J Chemother. 1995 Feb;7(1):38-41. doi: 10.1179/joc.1995.7.1.38.
The effects of pefloxacin on adenosine-diphosphate (ADP) and collagen-induced human platelet aggregation in vitro and ex vivo in patients suffering from chronic bronchitis were investigated. In the in vitro study carried out on platelets from 12 healthy volunteers, pefloxacin had no effect on platelet function even at a concentration of 10 mg/ml, which is 1,500 times higher than that reached in vivo. In the ex vivo study carried out in 10 patients, who received pefloxacin twice daily for 7-10 days as 400 mg oral dose, the drug did not influence platelet aggregation up to 24 hours after administration of the last oral dose.
研究了培氟沙星对慢性支气管炎患者体外和体内二磷酸腺苷（ADP）及胶原诱导的人血小板聚集的影响。在对12名健康志愿者的血小板进行的体外研究中，即使培氟沙星浓度达到10mg/ml（这比体内所能达到的浓度高1500倍），它对血小板功能也没有影响。在对10名患者进行的体内研究中，这些患者每天口服400mg培氟沙星，连续服用7 - 10天，每天两次，在最后一次口服给药后长达24小时内，该药物对血小板聚集没有影响。
