Morguet A J, Sandrock D, Stille-Siegener M, Figulla H R
Department of Cardiology, Georg August University, Göttingen, Germany.
J Nucl Med. 1995 Aug;36(8):1432-5.
Indium-111-antimyosin Fab imaging has been used to indicate myocardial injury. This report describes antimyosin accumulation in two patients with myocardial involvement in systemic lupus erythematosus. Both patients complained of chest pain, and significant stenoses of extramural coronary arteries were ruled out by angiography. The first patient, a 64-yr-old woman, had immunopathologic findings suggestive of systemic lupus. Indium-111-antimyosin Fab imaging showed myocardial tracer uptake. This prompted endomyocardial biopsy providing evidence of systemic lupus. The patient improved under immunosuppressive therapy. The second patient, a 47-yr-old man, had systemic lupus diagnosed by immunopathologic findings and skin biopsy. He had evidence of pericarditis on electrocardiography and echocardiography. Indium-111-antimyosin Fab imaging demonstrated additional myocardial involvement, which supported the initiation of immunosuppressive therapy. Our results suggest that 111In-antimyosin Fab imaging may provide valuable diagnostic information and influence patient management in systemic lupus erythematosus with suspected myocardial involvement.
铟 - 111抗肌凝蛋白Fab显像已被用于指示心肌损伤。本报告描述了两例系统性红斑狼疮累及心肌患者的抗肌凝蛋白蓄积情况。两名患者均主诉胸痛，血管造影排除了壁外冠状动脉的明显狭窄。首例患者为一名64岁女性，免疫病理学检查结果提示系统性红斑狼疮。铟 - 111抗肌凝蛋白Fab显像显示心肌有示踪剂摄取。这促使进行心内膜心肌活检，从而为系统性红斑狼疮提供了证据。该患者在免疫抑制治疗下病情好转。第二例患者为一名47岁男性，经免疫病理学检查结果和皮肤活检诊断为系统性红斑狼疮。他的心电图和超声心动图显示有心包炎迹象。铟 - 111抗肌凝蛋白Fab显像显示还有心肌受累，这支持了免疫抑制治疗的开始。我们的结果表明，铟 - 111抗肌凝蛋白Fab显像可能为疑似心肌受累的系统性红斑狼疮提供有价值的诊断信息并影响患者的治疗管理。
