5-氟尿嘧啶治疗继发的掌跖红细胞发育不良综合征的长期后遗症。
Long-term sequelae of Palmar-Plantar erythrodysaesthesia syndrome secondary to 5-fluorouracil therapy.
作者信息
Banfield G K, Crate I D, Griffiths C L
机构信息
Department of Surgical Oncology, Queen Elizabeth Military Hospital, Woolwich, London, UK.
出版信息
J R Soc Med. 1995 Jun;88(6):356P-357P.
Abstract
Palmar-Plantar erythrodyasesthesia syndrome has been reported as a temporary complication of 5-fluorouracil therapy consisting of a debilitating erythema and tenderness of the skin of hands and feet. The syndrome has previously been observed to respond rapidly to either temporary cessation of chemotherapy or pyridoxine with little residual disability. We report a case which was characterized by persistent morbidity necessitating prolonged discontinuation of treatment.
摘要
掌跖红细胞发育不全综合征已被报道为5-氟尿嘧啶治疗的一种暂时并发症，其表现为手足皮肤出现使人虚弱的红斑和压痛。此前观察到该综合征对暂时停止化疗或使用吡哆醇反应迅速，几乎没有残留残疾。我们报告了一例以持续发病为特征的病例，需要长期停止治疗。
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本文引用的文献
1
Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome.化疗相关的手足红斑感觉异常综合征
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2
Fluorouracil and the palmar-plantar erythrodysesthesia syndrome.氟尿嘧啶与手足红斑感觉异常综合征
Ann Intern Med. 1985 Mar;102(3):419. doi: 10.7326/0003-4819-102-3-419_1.
3
Fluorouracil-associated dermatitis of the hands and feet.氟尿嘧啶相关性手足皮炎
JAMA. 1985 Dec 27;254(24):3479.
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Fluorouracil and palmar-plantar erythrodysesthesia.氟尿嘧啶与手足红斑性感觉异常
Ann Intern Med. 1989 Nov 15;111(10):858. doi: 10.7326/0003-4819-111-10-858_1.
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Ann Intern Med. 1989 Oct 15;111(8):688-9. doi: 10.7326/0003-4819-111-8-688.
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