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Long-term sequelae of Palmar-Plantar erythrodysaesthesia syndrome secondary to 5-fluorouracil therapy.5-氟尿嘧啶治疗继发的掌跖红细胞发育不良综合征的长期后遗症。
J R Soc Med. 1995 Jun;88(6):356P-357P.
2
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Palmar-plantar erythrodysesthesia syndrome associated with short-term continuous infusion (5 days) of 5-fluorouracil.与短期连续输注（5天）5-氟尿嘧啶相关的手足红斑感觉异常综合征。
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Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome.化疗相关的手足红斑感觉异常综合征
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Is pyridoxine helpful in preventing palmar-plantar erythrodysesthesia associated with capecitabine?吡哆醇对预防与卡培他滨相关的手足红斑性感觉异常是否有帮助？
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Front Oncol. 2025 Mar 31;15:1542315. doi: 10.3389/fonc.2025.1542315. eCollection 2025.
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Prophylactic pyridoxine was not able to reduce the incidence of capecitabine-induced hand-foot syndrome: A meta-analysis.预防性使用吡哆醇不能降低卡培他滨引起的手足综合征的发生率：一项荟萃分析。
Biomed Rep. 2013 Nov;1(6):873-878. doi: 10.3892/br.2013.161. Epub 2013 Aug 28.
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Pyridoxine for prevention of hand-foot syndrome caused by chemotherapy: a systematic review.用于预防化疗引起的手足综合征的维生素B6：一项系统评价
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[Hand-foot syndrome with capecitabine therapy].[卡培他滨治疗所致手足综合征]
Hautarzt. 2007 Jun;58(6):532-6. doi: 10.1007/s00105-006-1183-y.

本文引用的文献

1
Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome.化疗相关的手足红斑感觉异常综合征
Ann Intern Med. 1984 Dec;101(6):798-9. doi: 10.7326/0003-4819-101-6-798.
2
Fluorouracil and the palmar-plantar erythrodysesthesia syndrome.氟尿嘧啶与手足红斑感觉异常综合征
Ann Intern Med. 1985 Mar;102(3):419. doi: 10.7326/0003-4819-102-3-419_1.
3
Fluorouracil-associated dermatitis of the hands and feet.氟尿嘧啶相关性手足皮炎
JAMA. 1985 Dec 27;254(24):3479.
4
Fluorouracil and palmar-plantar erythrodysesthesia.氟尿嘧啶与手足红斑性感觉异常
Ann Intern Med. 1989 Nov 15;111(10):858. doi: 10.7326/0003-4819-111-10-858_1.
5
Pyridoxine for the palmar-plantar erythrodysesthesia syndrome.用于手足掌红斑感觉异常综合征的维生素B6
Ann Intern Med. 1989 Oct 15;111(8):688-9. doi: 10.7326/0003-4819-111-8-688.

5-氟尿嘧啶治疗继发的掌跖红细胞发育不良综合征的长期后遗症。

Long-term sequelae of Palmar-Plantar erythrodysaesthesia syndrome secondary to 5-fluorouracil therapy.

作者信息

Banfield G K, Crate I D, Griffiths C L

机构信息

Department of Surgical Oncology, Queen Elizabeth Military Hospital, Woolwich, London, UK.

出版信息

J R Soc Med. 1995 Jun;88(6):356P-357P.

PMID:7629773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1295248/
Abstract

Palmar-Plantar erythrodyasesthesia syndrome has been reported as a temporary complication of 5-fluorouracil therapy consisting of a debilitating erythema and tenderness of the skin of hands and feet. The syndrome has previously been observed to respond rapidly to either temporary cessation of chemotherapy or pyridoxine with little residual disability. We report a case which was characterized by persistent morbidity necessitating prolonged discontinuation of treatment.

摘要

掌跖红细胞发育不全综合征已被报道为5-氟尿嘧啶治疗的一种暂时并发症，其表现为手足皮肤出现使人虚弱的红斑和压痛。此前观察到该综合征对暂时停止化疗或使用吡哆醇反应迅速，几乎没有残留残疾。我们报告了一例以持续发病为特征的病例，需要长期停止治疗。