Koike T, Hamaguchi M
Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine.
Nihon Rinsho. 1995 Jul;53(7):1578-84.
Cadherins are a family of Ca(2+)-dependent cell adhesion molecules that mediate cell adhesion by homophilic interaction and play critical role in multicellular organ formation. Recent progress revealed the three-dimensional structure of extracellular cadherin repeats that made great progress in the study of cell adhesion by cadherins. The perturbation of cadherin function in transformed cells results in inhibition of cell-cell adhesion, that appears to promote metastasis and invasiveness of tumor cells. Expression as well as modifications of catenins, which link cadherins to cytoskeletons, have crucial effects on this purturbation mechanisms. Tyrosine phosphorylation of cadherin catenin complex may be the important regulatory mechanism.
钙黏蛋白是一类依赖钙离子的细胞黏附分子家族，通过同源相互作用介导细胞黏附，并在多细胞器官形成中发挥关键作用。最近的研究进展揭示了细胞外钙黏蛋白重复序列的三维结构，这在钙黏蛋白介导的细胞黏附研究方面取得了重大进展。转化细胞中钙黏蛋白功能的紊乱会导致细胞间黏附受到抑制，这似乎促进了肿瘤细胞的转移和侵袭。连环蛋白将钙黏蛋白与细胞骨架相连，其表达以及修饰对这种紊乱机制具有至关重要的影响。钙黏蛋白-连环蛋白复合体的酪氨酸磷酸化可能是重要的调节机制。
