Shiozaki H, Gofuku J, Inoue M, Tamura S
Department of Surgery II, Osaka University Medical School.
Nihon Rinsho. 1995 Jul;53(7):1602-6.
The immunostaining (ABC method) of E-cadherin and alpha-catenin were performed on 46 esophageal cancers, 67 gastric cancers, 100 colon cancers. E-cadherin and alpha-catenin expression was evaluated as preserved and reduced according to the proportion of positive cells, respectively. The reduction of alpha-catenin expression was more significantly related to lymph node metastasis than that of E-cadherin. Furthermore, the frequency of hematogenous liver metastasis in preserved E-cadherin expression and reduced alpha-catenin expression was significantly higher than that in another combination of E-cadherin and alpha-catenin expression, in gastric and colon cancer. The reduction of alpha-catenin expression was associated with declined intercellular adhesiveness, which occasionally was not accompanied by reduction of E-cadherin. Therefore, the expression of alpha-catenin might more sensitively indicated cell-cell adhesion, predicting tumor metastasis.
对46例食管癌、67例胃癌和100例结肠癌进行了E-钙黏蛋白和α-连环蛋白的免疫染色（ABC法）。根据阳性细胞比例，分别将E-钙黏蛋白和α-连环蛋白的表达评估为保留和降低。α-连环蛋白表达降低与淋巴结转移的相关性比E-钙黏蛋白更显著。此外，在胃癌和结肠癌中，E-钙黏蛋白表达保留而α-连环蛋白表达降低的患者血行肝转移频率显著高于E-钙黏蛋白和α-连环蛋白表达的其他组合。α-连环蛋白表达降低与细胞间黏附性下降有关，偶尔并不伴有E-钙黏蛋白的降低。因此，α-连环蛋白的表达可能更敏感地指示细胞间黏附，预测肿瘤转移。
