ter Maaten J C, Strack van Schijndel R J, Jukema G J, Kerkhof S C
Afd. Acute Inwendige Geneeskunde, Academisch Ziekenhuis Vrije Universiteit, Amsterdam.
Ned Tijdschr Geneeskd. 1995 Jul 22;139(29):1501-4.
A 70-year-old woman suffering from atrial fibrillation was treated with amiodarone, but developed acute respiratory failure necessitating mechanical ventilation for four weeks. Pulmonary function remained restrictively impaired after weaning from the ventilation, due to pulmonary fibrosis. Pulmonary toxicity is a well-known adverse reaction to amiodarone, but it rarely requires mechanical ventilation. The Netherlands Centre for Monitoring of Adverse Reactions to Drugs received II reports of this life-threatening reaction since 1976.
一名70岁患心房颤动的女性接受了胺碘酮治疗，但出现急性呼吸衰竭，需要机械通气四周。脱机后，由于肺纤维化，肺功能仍存在限制性损害。肺毒性是胺碘酮众所周知的不良反应，但很少需要机械通气。自1976年以来，荷兰药物不良反应监测中心收到了11例这种危及生命反应的报告。
